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Decoding the Role of Chimeric RNA in Cellular Processes | #neurological disorders

Decoding the Role of Chimeric RNA in Cellular Processes

Chimeric RNA, a unique class of RNA molecules formed through various molecular mechanisms, such as trans-splicing, read-through transcription, and fusion genes. These hybrid transcripts play a significant role in diverse biological processes and have gained substantial attention in recent

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Targeting RNA Splicing: Mechanisms and Strategies | #RNA-Seq

Targeting RNA Splicing: Mechanisms and Strategies

RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains both coding regions (exons) and non-coding regions (introns). RNA splicing removes the introns from the pre-mR

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Variant Analysis Workflow in Bioinformatics | #Bioinformatics Analysis

Variant Analysis Workflow in Bioinformatics

Rare DNA changes within a population of cells are the first manifestations of mutations, which are the fuel for evolution. The research of genomic variation between species and individual organisms has been revolutionized by next-generation sequencing (NGS) technologies.

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Hybridization Capture and PCR Amplification: Comparing Two Key Enrichment Strategies in NGS | #Hybridization-Based Target Enrichment

Hybridization Capture and PCR Amplification: Comparing Two Key Enrichment Strategies in NGS

Moreover, targeted NGS simplifies downstream bioinformatics analysis, provides greater sequencing depth, and increases sequencing sensitivity, which is valuable in variant calling and gene expression studies. Two fundamental target enrichment strategies can be employed prior to NGS – cap

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Microbiome Profiling by Sequencing: Definitions and Technologies | #Single-cell sequencing

Microbiome Profiling by Sequencing: Definitions and Technologies

Advanced sequencing technologies can provide comprehensive genetic information of all kinds of microorganisms including bacteria, archaea, fungi, and viruses, of which the majority are unculturable and not formerly studied. The sequencing technologies offer solutions for precise identifica

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